For research and laboratory use only. Not for human or veterinary consumption.

This product is sold for research purposes only. It is not intended for human consumption, diagnosis, treatment, cure, or prevention of any disease. Purchaser acknowledges that this material is for laboratory research use only.

Analogs

99.5% Purity

10mg lyophilized vial

IGF-1 LR3

An 83-amino acid synthetic analog of human insulin-like growth factor 1 with reduced binding protein affinity and extended half-life, studied for anabolic and tissue growth effects in preclinical research. Premium Research Peptide.

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$89.99 Bundle price $89.99
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Compound Information

Technical specifications

🔬 Molecular Profile

What Is IGF-1 LR3?

Type
Synthetic IGF-1 analog
CAS Number
143045-27-6
Molecular Weight
9,117.60 g/mol
Amino Acids
83
Formula
C400H625N111O115S9
Sequence
MFPAMPLSSL FVNGPRTLCG...

🧬 Structural Modifications

How It Differs from Native IGF-1

N-terminal extension
+13 amino acids (MFPAMPLLSLFVN)
Position 3 substitution
Glu → Arg
Total length
83 vs 70 amino acids
IGFBP affinity
Dramatically reduced
IGF-1R affinity
Retained

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Sources & References

Peer-reviewed research

Biochemical Journal
Insulin-like growth factor-I (IGF-I) and especially IGF-I variants are anabolic in dexamethasone-treated rats
1992 • DOI: 10.1042/bj2820091 • PMID: 1371669 Tomas FM, Knowles SE, Owens PC et al. View Source
Journal of Endocrinology
Superior potency of infused IGF-I analogues which bind poorly to IGF-binding proteins is maintained when administered by injection
1996 • DOI: 10.1677/joe.0.1500077 • PMID: 8708565 Tomas FM, Lemmey AB, Read LC, Ballard FJ
Journal of Endocrinology
IGF-binding proteins are multifunctional and act via IGF-dependent and -independent mechanisms
2002 • DOI: 10.1677/joe.0.1750019 • PMID: 12379487 Mohan S, Baylink DJ
American Journal of Pathology
IGF-1 has plaque-stabilizing effects in atherosclerosis by altering vascular smooth muscle cell phenotype
2011 • DOI: 10.1016/j.ajpath.2010.10.007 • PMID: 21281823 von der Thüsen JH, Borensztajn KS, Moimas S et al.
Journal of Endocrinology
Long R3 insulin-like growth factor-I (IGF-I) infusion stimulates organ growth but reduces plasma IGF-I, IGF-II and IGF binding protein concentrations in the guinea pig
1995 • DOI: 10.1677/joe.0.1460247 • PMID: 7561636 Conlon MA, Tomas FM, Owens PC et al. View Source

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Certificate of Analysis

Researcher verification

Elev-8 Labs sells research peptides exclusively to qualified researchers and laboratories for in vitro and laboratory use. Please confirm before continuing.

By proceeding, you affirm the statements above are true: products are not for human or veterinary use, not for use in diagnostic procedures, and have not been evaluated by the U.S. Food and Drug Administration.